Practice Questions

TLS Online TPP Program

#Question id: 887

Polypeptides fold rapidly by a stepwise process, how does the polypeptide chain arrive at its native conformation?

#Part-A Aptitude & General Biotechnology

proteins appear to fold in a hierarchical manner, with small local elements of structure forming and then to yield larger elements, which coalesce with other such elements to form yet larger elements and converted into its native conformation
A protein-folding pathway has been highly successful in predicting the three-dimensional structure of small proteins from their amino acid sequence atleast 156 amino acid residue that have acquired their final structure
Vander waal interaction play a significant role throughout the process, as the aggregation of nonpolar amino acid side chains provides an entropic stabilization to intermediates and, eventually, to the final folded structure
The native conformation of the protein folding by stepwise manner such as unfolded→transition state→molten globule→folded conformation by decreasing the free energy