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TLS Online TPP Program

#Id: 10314

Tumors that arise from exposure to mutagens, such as melanomas (UV light) and lung carcinomas (tobacco smoke) the number of mutations may be hundredfold greater than this. These altered proteins are known as neo-antigens

#Section 2: General Biology #T cells #Part B Pointers
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TLS Online TPP Program

#Id: 8337

#Section 3: Genetics, Cellular and Molecular Biology

Profilin – G-actin nucleotide exchange (ADP to ATP) 
Cofilin – F-actin disassembly
Thymosin B-4 – G-actin monomer sequestering
TLS Online TPP Program

#Id: 8336

#Section 3: Genetics, Cellular and Molecular Biology

Actin filament treadmilling is accelerated by:

Profilin and Cofilin
TLS Online TPP Program

#Id: 8335

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8334

#Section 3: Genetics, Cellular and Molecular Biology

Phalloidin 
isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.
TLS Online TPP Program

#Id: 8333

#Section 3: Genetics, Cellular and Molecular Biology

Jasplakinolide,
a sponge toxin, enhances nucleation by binding and stabilizing actin dimers and lowering the Cc.
TLS Online TPP Program

#Id: 8332

#Section 3: Genetics, Cellular and Molecular Biology

Latrunculin, 
a toxin secreted by sponges, binds and sequesters G-actin