The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 9158

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 7761

#Section 2: General Biology

A covalent bond is a chemical bond that occurs when two or more atoms share electrons. The sharing of electrons helps complete the outer shell, or valence shell, of both atoms. The sharing of electrons creates a stable balance of attractive and repulsive forces between atoms.

TLS Online TPP Program

#Id: 10337

#Section 2: General Biology

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7(CD80/86)

ICAM-1

MHC-1 and 2 both

CD 22

TLS Online TPP Program

#Id: 2246

#Section 3: Genetics, Cellular and Molecular Biology

Some people have an allele called Δ32 at the CCR5 locus in which 32 bp are deleted.

CCR5 that plays a role in inflammatory response. Unfortunately, this protein is also a key to human immunodeficiency virus (HIV) infection. The virus binds to a loop of the CCR5 protein and then enters the cell.

The missing part of the gene codes for the loop in the protein to which the virus attaches. 

TLS Online TPP Program

#Id: 8146

#Section 3: Genetics, Cellular and Molecular Biology