In skeletal muscle cells, 

a low cytosolic Ca+2 level is maintained by a unique Ca+2 ATPase that continually pumps Ca+2 ions from

the cytosol containing the myofibrils into the SR, establishes a reservoir of Ca+2 in the SR.

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cyclin-CDK complexes preferentially phosphorylate

serine and threonine residues when they are found within the consensus sequence:

[S/T]PX[R/K]K 

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G1 Cyclin–CDKs

In human - cyclin D-CDK 4 

cyclin D-CDK 6

In budding yeast - CIn 3-Cdc 28 

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G1/S Cyclin–CDKs

In human - cyclin E-CDK 2 

In budding yeast - CIn 1/2-Cdc 28

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S phase Cyclin–CDKs

In human - cyclin A-CDK 2 

In budding yeast - CIb 5/6-Cdc 28

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M phase Cyclin–CDKs

In human - cyclin A-CDK 1

cyclin B-CDK 1

In budding yeast - CIb 1/2/3/4-Cdc 28