T-independent response

Type 1 T-independent (TI-1) antigens bind to B cells through both Ig and innate immune receptors. LPS from Gram negative organisms binds to B cells via both mIg and TLR, resulting in signaling from both receptors. 

TLS Online TPP Program

#Id: 10342

#Section 2: General Biology

TLS Online TPP Program

#Id: 10343

#Section 2: General Biology

The heavy chain is then expressed on the cell surface in combination with the surrogate light chain, which is made up of VpreB and λ5. 

TLS Online TPP Program

#Id: 10344

#Section 2: General Biology

B- cell maturation

TLS Online TPP Program

#Id: 10345

#Section 2: General Biology

T1 and T2 Transitional B Cells

TLS Online TPP Program

#Id: 10346

#Section 2: General Biology

T1 cells are mIgMhi, mIgD -/lo, CD21-, CD23-, CD24+, and CD93+. 

T2 cells differ from T1 cells in having higher levels of mIgD and in expressing CD21 and CD23. 

TLS Online TPP Program

#Id: 10347

#Section 2: General Biology

Transitional B cells bound for a follicular fate undergo positive and negative selection in the spleen.