Class II MHC transcriptional activator called CIITA and another transcription factor called RFX, have both been shown to activate the promoter of class II MHC genes.

Defects in these transcription factors cause one form of bare lymphocyte syndrome.

TLS Online TPP Program

#Id: 10298

#Section 2: General Biology

T-cell education

TLS Online TPP Program

#Id: 10299

#Section 2: General Biology

Lineage commitment

TLS Online TPP Program

#Id: 10300

#Section 2: General Biology

T-Cell Activation and Differentiation

TLS Online TPP Program

#Id: 10301

#Section 2: General Biology

Three signals are required for activation of a naïve T cell

TLS Online TPP Program

#Id: 10302

#Section 2: General Biology

Positive Costimulatory Receptors: ICOS

ICOS binds to another member of the growing B7 family, ICOS-ligand (ICOS-L), which is also expressed on a subset of activated APCs.

ICOS plays a key role in maintaining the activity of already differentiated effector and memory T cells.

TLS Online TPP Program

#Id: 10303

#Section 2: General Biology

T-cell costimulatory