Class II MHC transcriptional activator called CIITA and another transcription factor called RFX, have both been shown to activate the promoter of class II MHC genes.

Defects in these transcription factors cause one form of bare lymphocyte syndrome.

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B cell is type of lymphocyte.

B cell synthesized and maturation in bone marrow.

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They are pAPCs

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Cause humoral immunity or antibodies mediated immunity

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Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7(CD80/86)

ICAM-1

MHC-1 and 2 both

CD 22

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Step involve in formation of mature B-cell

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#Section 2: General Biology