Highest rates of substitutions in regions of the gene that have the least effect on function, such as the third position of a codon, flanking regions, and introns.

TLS Online TPP Program

#Id: 8167

#Section 3: Genetics, Cellular and Molecular Biology

Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 8976

#Section 3: Genetics, Cellular and Molecular Biology

Rate of evolution = Number of amino acid different / Total time

Hint:  Total time = 2xT

Rate of Change per amino acid per year = rate of evolution / total amino acid

TLS Online TPP Program

#Id: 10352

#Section 2: General Biology

B-cell activation

TLS Online TPP Program

#Id: 8990

#Section 3: Genetics, Cellular and Molecular Biology

Adaptive introgression

When the incorporation of a foreign variant leads to an increase of the fitness of the recipient pool.

TLS Online TPP Program

#Id: 9171

#Section 3: Genetics, Cellular and Molecular Biology

Determining allelic frequencies at equilibrium