Neutral selection (Ka/Ks = 1)

Positive selection (Ka/Ks > 1)

Purifying selection (Ka/Ks < 1)

TLS Online TPP Program

#Id: 8166

#Section 3: Genetics, Cellular and Molecular Biology

CFTR protein contains

a di-acidic sorting signal that binds to the Sec24 subunit

of the COPII vesicle coat and is necessary for transport of

the CFTR protein out of the ER.

TLS Online TPP Program

#Id: 8165

#Section 3: Genetics, Cellular and Molecular Biology

TANGO1 is an ER membrane protein that acts as a cargo receptor for collagen.

TLS Online TPP Program

#Id: 8164

#Section 3: Genetics, Cellular and Molecular Biology

Vesicles coated with GGA proteins and clathrin bind to proteins containing 

Asp-X-Leu-Leu and Asp-Phe-Gly-X-Φ sequences

TLS Online TPP Program

#Id: 8163

#Section 3: Genetics, Cellular and Molecular Biology

Vesicles coated with AP1 and clathrin bind to  proteins containing a Tyr-X-X-Φ sequence

TLS Online TPP Program

#Id: 8162

#Section 3: Genetics, Cellular and Molecular Biology

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 8161

#Section 3: Genetics, Cellular and Molecular Biology

KKXX sorting signal,

binds to a complex of the COPI α and β subunits