The neutral-mutation hypothesis proposes that most molecular variation is neutral with regard to natural selection and is shaped largely by mutation and genetic drift.

TLS Online TPP Program

#Id: 8967

#Section 3: Genetics, Cellular and Molecular Biology

Nonsynonymous mutations, on the other hand, alter the amino acid sequence of the protein and in many cases are detrimental to the fitness of the organism, so most of these mutations are eliminated by natural selection.

TLS Online TPP Program

#Id: 8849

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

TLS Online TPP Program

#Id: 8610

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8151

#Section 3: Genetics, Cellular and Molecular Biology

Sec12

acts as a GEF factor for Sar1

TLS Online TPP Program

#Id: 8869

#Section 3: Genetics, Cellular and Molecular Biology

Yeast cells with a defective wee1+ gene activate mitotic CDKs prematurely and premature entry into mitosis (smaller than normal cells