Molecules are groups of atoms that behave as a single unit.

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#Section 3: Genetics, Cellular and Molecular Biology

In selective autophagy

specific cargo is packaged into autophagosomes that tend to contain little cytosol, mediates the degradation of worn out, or unwanted, mitochondria, peroxisomes, ribosomes, and ER; used to destroy invading microbes.

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#Section 3: Genetics, Cellular and Molecular Biology

In nonselective autophagy, a bulk portion of cytoplasm is sequestered in autophagosomes

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#Section 3: Genetics, Cellular and Molecular Biology

Autophagy can be either

• Nonselective autophagy

• Selective autophagy

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#Section 3: Genetics, Cellular and Molecular Biology

Autophagy occurs in the following sequence of steps:

Induction by activation of mTOR complex 1

• Nucleation of autophagosome formation by ATG9

• Closure of the membrane cup to form autophagosome

• Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

• Digestion of the inner membrane and the lumenal contents of the autophagosome

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#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8211

#Section 3: Genetics, Cellular and Molecular Biology

Autophagosome, or autophagic vesicle

formation of a flattened double-membrane cup-shaped structure that envelops a region of the cytosol or an entire organelle.