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TLS Online TPP Program

#Id: 7929

The ER captures selected proteins from the cytosol as they are being synthesized. These are of two types:

Transmembrane proteins

Water-soluble proteins

#Section 3: Genetics, Cellular and Molecular Biology #Endoplasmic Reticulum #Part B Pointers
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TLS Online TPP Program

#Id: 10320

#Section 2: General Biology

The tumor cells may acquire additional oncogenic mutations that allow them to escape the immune system.
TLS Online TPP Program

#Id: 10321

#Section 2: General Biology

The tumor down regulates the expression of class I MHC proteins
TLS Online TPP Program

#Id: 10322

#Section 2: General Biology

Sometimes the tumor cells up-regulate the expression of anti-apoptotic proteins like BCL-2.
TLS Online TPP Program

#Id: 10323

#Section 2: General Biology

TLS Online TPP Program

#Id: 10324

#Section 2: General Biology

PD-1 has a structure similar to CTLA-4 and when activated negatively regulates T-cell function by inducing apoptosis of activated T cells. 
TLS Online TPP Program

#Id: 10325

#Section 2: General Biology

Monoclonal Antibodies Against Immune Checkpoint Molecules to Treat Cancers