The SRP and the nascent polypeptide chain–ribosome complex bind to the SRP receptor in the ER membrane. This interaction is strengthened by the binding of GTP to both the SRP and its receptor.

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Sec12

acts as a GEF factor for Sar1

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#Section 3: Genetics, Cellular and Molecular Biology

Sar1 is the only GTPase switch protein activated at the ER membrane

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#Section 3: Genetics, Cellular and Molecular Biology

ARF and Sar1 similar to Ras

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#Section 3: Genetics, Cellular and Molecular Biology

Depolymerization of the clathrin coat into triskelions  by Cytosolic Hsp70

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#Section 3: Genetics, Cellular and Molecular Biology

A clathrin molecule,

called a triskelion, is composed of : 

Three heavy chains

Three light chains

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#Section 3: Genetics, Cellular and Molecular Biology