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TLS Online TPP Program

#Id: 7939

The GTPase cycle analogous to the GTP hydrolysis coupled to the initiation of translation on the ribosome.

#Section 3: Genetics, Cellular and Molecular Biology #Endoplasmic Reticulum #Part B Pointers
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TLS Online TPP Program

#Id: 8614

#Section 3: Genetics, Cellular and Molecular Biology

Two inhibitory phosphorylations on CDK play a critical role in controlling CDK activity:
Y15
T14
TLS Online TPP Program

#Id: 8615

#Section 3: Genetics, Cellular and Molecular Biology

Y15 & T14 are situated in the G-loop of the CDK, containing the consensus sequence GEGT14Y15GVV
TLS Online TPP Program

#Id: 8616

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation of T14 and Y15 in this G-loop
introduces negative charge that electrostatically interferes with the binding of ATP in the catalytic pocket.
TLS Online TPP Program

#Id: 8617

#Section 3: Genetics, Cellular and Molecular Biology

Wee1 kinase Inhibits CDKs in all organisms
TLS Online TPP Program

#Id: 8618

#Section 3: Genetics, Cellular and Molecular Biology

Cdc25 phosphatase Activates CDKs in fission yeast
TLS Online TPP Program

#Id: 8619

#Section 3: Genetics, Cellular and Molecular Biology

INK4s
bind to CDK4 and CDK6 monomers, blocking their interaction with cyclin D