Negatively charged amino acids have four ionisations zones

1. 1--------pK1 – charge +1

2. pK1---------pKr charge 0

3. pKr---------pK2 charge -1

4. pK2---------14 charge -2

TLS Online TPP Program

#Id: 8408

#Section 3: Genetics, Cellular and Molecular Biology

Tropomyosin (TM) is a ropelike molecule, about 40 nm in length, binds to 7 actin subunits in an actin filament.

TLS Online TPP Program

#Id: 8406

#Section 3: Genetics, Cellular and Molecular Biology

Vertebrate skeletal muscle contraction, also depends on set of specialized accessory proteins that are closely associated with the actin thin filaments:

a) Tropomyosin

b) Troponin

TLS Online TPP Program

#Id: 8405

#Section 3: Genetics, Cellular and Molecular Biology

Muscle contraction depends on two processes that consume enormous amounts of ATP: 

1. Filament sliding, driven by the ATPase of the myosin

2. Ca2+ pumping, driven by the Ca2+ ATPase

TLS Online TPP Program

#Id: 8404

#Section 3: Genetics, Cellular and Molecular Biology

The increase in Ca2+ concentration is transient because the Ca2+ is rapidly pumped back into the SR by an abundant, Ca2+ ATPase.

TLS Online TPP Program

#Id: 8403

#Section 3: Genetics, Cellular and Molecular Biology

AP activates a  voltage gated Ca2+ channel in the T-tubule membrane, it triggers the opening of a Ca2+ -release channel in the closely associated SR membrane

TLS Online TPP Program

#Id: 8402

#Section 3: Genetics, Cellular and Molecular Biology

The arrival of a nerve impulse at a neuromuscular junction triggers an action potential in sarcolemma.