Negatively charged amino acids have four ionisations zones

1. 1--------pK1 – charge +1

2. pK1---------pKr charge 0

3. pKr---------pK2 charge -1

4. pK2---------14 charge -2

TLS Online TPP Program

#Id: 8532

#Section 3: Genetics, Cellular and Molecular Biology

Catastrophe 

The change from growth to shrinkage

TLS Online TPP Program

#Id: 8531

#Section 3: Genetics, Cellular and Molecular Biology

Dynamic instability 

Rapid interconversion between a growing and shrinking state, at a uniform free tubulin concentration

TLS Online TPP Program

#Id: 8528

#Section 3: Genetics, Cellular and Molecular Biology

Polyglutamylation has a key role in the beating of cilia and flagella

TLS Online TPP Program

#Id: 8527

#Section 3: Genetics, Cellular and Molecular Biology

Kinesin-1 associates preferentially with detyrosylated and acetylated microtubules.

TLS Online TPP Program

#Id: 8526

#Section 3: Genetics, Cellular and Molecular Biology

Polyglutamylation and polyglycylation are likely mutually exclusive, so they would not normally occur at the same time & both can enhance microtubule stability,

TLS Online TPP Program

#Id: 8525

#Section 3: Genetics, Cellular and Molecular Biology

Detyrosylated microtubules are more stable, because they are more resistant to depolymerization by kinesin-13 and related proteins.