CFTR protein contains

a di-acidic sorting signal that binds to the Sec24 subunit

of the COPII vesicle coat and is necessary for transport of

the CFTR protein out of the ER.

TLS Online TPP Program

#Id: 8345

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8343

#Section 3: Genetics, Cellular and Molecular Biology

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8342

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8341

#Section 3: Genetics, Cellular and Molecular Biology

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

TLS Online TPP Program

#Id: 8340

#Section 3: Genetics, Cellular and Molecular Biology

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.

TLS Online TPP Program

#Id: 8339

#Section 3: Genetics, Cellular and Molecular Biology

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end