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In mammalian cells, Rab5 protein (early endosomes) and its effector protein known as EEA1 (early endosome antigen 1)

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#Section 3: Genetics, Cellular and Molecular Biology

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In budding yeast CKI p27 = Sic1 in metazoans

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When CDK activity is low= helicases are loaded in G1
When CDK activity is high= helicases are activated in
S, G2 & M

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Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

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