Zellweger syndrome

Autosomal recessive Mutations in any of a dozen different peroxins, the most common being Pex1, cause an impairment in peroxisomal protein import.

TLS Online TPP Program

#Id: 7324

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8608

#Section 3: Genetics, Cellular and Molecular Biology

There are three D cyclins in mammals:

cyclins D1, D2, and D3

TLS Online TPP Program

#Id: 8334

#Section 3: Genetics, Cellular and Molecular Biology

Phalloidin 

isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.

TLS Online TPP Program

#Id: 10291

#Section 2: General Biology

The second phase of T-cell development

1.Positive selection: Selection for those cells whose T-cell receptors engage self-MHC.

2.Negative selection: Selection against those cells whose T-cell receptors bind too strongly to self-peptide/MHC combinations.

3.Lineage commitment: Commitment of thymocytes to effector cell lineages, including CD4 helper or CD8 cytotoxic populations

TLS Online TPP Program

#Id: 8166

#Section 3: Genetics, Cellular and Molecular Biology

CFTR protein contains

a di-acidic sorting signal that binds to the Sec24 subunit

of the COPII vesicle coat and is necessary for transport of

the CFTR protein out of the ER.