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TLS Online TPP Program

#Id: 8343

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly


#Section 3: Genetics, Cellular and Molecular Biology #MICROFILAMENTS #Part B Pointers
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TLS Online TPP Program

#Id: 8650

#Section 3: Genetics, Cellular and Molecular Biology

G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition
TLS Online TPP Program

#Id: 8651

#Section 3: Genetics, Cellular and Molecular Biology

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1
TLS Online TPP Program

#Id: 8652

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8653

#Section 3: Genetics, Cellular and Molecular Biology

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.
TLS Online TPP Program

#Id: 8654

#Section 3: Genetics, Cellular and Molecular Biology

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase
TLS Online TPP Program

#Id: 8655

#Section 3: Genetics, Cellular and Molecular Biology