formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8886

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8887

#Section 3: Genetics, Cellular and Molecular Biology

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

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#Id: 8888

#Section 3: Genetics, Cellular and Molecular Biology

A key function of mitotic CDKs, together with other protein kinases and ubiquitin-protein ligases, is to induce the formation of the mitotic spindle, also known as the mitotic apparatus.

TLS Online TPP Program

#Id: 8889

#Section 3: Genetics, Cellular and Molecular Biology

Centrosomes contain γ tubulin, which forms specific ringlike complexes (γ TuRCs) that, have the ability to nucleate microtubules and form a bipolar spindle

TLS Online TPP Program

#Id: 8890

#Section 3: Genetics, Cellular and Molecular Biology

Mitotic spindle attach to chromosomes via specialized protein structures known as kinetochores

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#Id: 8891

#Section 3: Genetics, Cellular and Molecular Biology

Kinetochores assemble on regions of chromosomal DNA marked by a centromere-specific H3 histone variant called CENP-A.