WASp activation requires two signals (This type of two-signal input, called coincidence detection):

1. regulatory phospholipid PIP2

2. small GTP-binding protein Cdc42

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Kinesin-1 

is regulated by a 

head-to-tail interaction

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Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene

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Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin.