The nitrate reductase dimer- Three binding domains

TLS Online TPP Program

#Id: 8971

#Section 3: Genetics, Cellular and Molecular Biology

The Death of a Gene

When a gene is duplicated, the new copy is often dead-on arrival (lacks the regulatory elements). 

TLS Online TPP Program

#Id: 2244

#Section 3: Genetics, Cellular and Molecular Biology

When a nonfunctioning duplicate is fixed in the population, or a functioning gene becomes nonfunctional, the result is a genetic skeleton called a pseudogene.

Deletions are important in shaping the genome.

TLS Online TPP Program

#Id: 2245

#Section 3: Genetics, Cellular and Molecular Biology

Deletion plays a key role in gene trafficking.which is the movement of genes to new sites in the genome.

TLS Online TPP Program

#Id: 2246

#Section 3: Genetics, Cellular and Molecular Biology

Some people have an allele called Δ32 at the CCR5 locus in which 32 bp are deleted.

CCR5 that plays a role in inflammatory response. Unfortunately, this protein is also a key to human immunodeficiency virus (HIV) infection. The virus binds to a loop of the CCR5 protein and then enters the cell.

The missing part of the gene codes for the loop in the protein to which the virus attaches. 

TLS Online TPP Program

#Id: 8972

#Section 3: Genetics, Cellular and Molecular Biology

Gene Structure

The genes that code for many proteins are broken into pieces. These pieces—the exons—are separated by stretches of noncoding DNA—the introns

TLS Online TPP Program

#Id: 8973

#Section 3: Genetics, Cellular and Molecular Biology

The current record holder is the gene Dscam in Drosophila. Alternative splicing of its 95 exons could potentially produce more than 38,000 kinds of proteins from this single gene.