The short (∼20 amino acid) C-terminal tails of both α- and β-tubulin that protrude from the microtubule are enriched in glutamic and aspartic acids, the surface of the microtubule possesses a net negative charge.

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#Id: 8151

#Section 3: Genetics, Cellular and Molecular Biology

Sec12

acts as a GEF factor for Sar1

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#Id: 8037

#Section 2: General Biology

Lys & Arg have ionisation series

1------pK1-----pK2--------pKr------14

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#Id: 8884

#Section 3: Genetics, Cellular and Molecular Biology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.

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#Id: 8524

#Section 3: Genetics, Cellular and Molecular Biology

Detyrosylation 

tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits. 

TLS Online TPP Program

#Id: 9192

#Section 3: Genetics, Cellular and Molecular Biology