TLS Online TPP Program

#Id: 7965

#Section 3: Genetics, Cellular and Molecular Biology

Unassembled or misfolded proteins in the ER are often transported back to the cytosol, where they are degraded in the ubiquitin-proteasome pathway

TLS Online TPP Program

#Id: 8540

#Section 3: Genetics, Cellular and Molecular Biology

Dynein-related transport requires dynactin, that links dynein to its cargo

TLS Online TPP Program

#Id: 8328

#Section 3: Genetics, Cellular and Molecular Biology

Hydrolysis of the bound nucleotide reduces the binding affinity of the subunit for neighbouring subunits and makes it more likely to dissociate from each end of the filament.

T form that adds to the filament and the D form that leaves.

TLS Online TPP Program

#Id: 10326

#Section 2: General Biology

Antibodies against 

CTLA-4

PD-L1 or PD-1

A CTLA-4-blocking antibody, ipilimumab

TLS Online TPP Program

#Id: 8353

#Section 3: Genetics, Cellular and Molecular Biology

A second NPF is a large protein complex called WAVE

and requires small GTP-binding protein Rac1.