At the same time that Cdc25C is being activated, mitotic CDKs and Plk1 phosphorylate Wee1, which targets it for destruction through a phosphobinding SCF protein-ubiquitin ligase. This forms positive feedback loop 2

TLS Online TPP Program

#Id: 8161

#Section 3: Genetics, Cellular and Molecular Biology

KKXX sorting signal,

binds to a complex of the COPI α and β subunits

TLS Online TPP Program

#Id: 8160

#Section 3: Genetics, Cellular and Molecular Biology

The KDEL receptor and other membrane proteins that

are transported Golgi to ER contain 

Lys-Lys-X-X sequence at C-terminal

TLS Online TPP Program

#Id: 8159

#Section 3: Genetics, Cellular and Molecular Biology

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 8158

#Section 3: Genetics, Cellular and Molecular Biology

Soluble ER-resident proteins contain C-terminal KDEL sorting signal that allows them to be retrieved. 

TLS Online TPP Program

#Id: 8157

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8156

#Section 3: Genetics, Cellular and Molecular Biology

Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals