Genetic drift 

Genetic drift is an evolutionary force, in which allelic frequency change over generation Just by chance (sampling error). 

The deviations from the expected ratios are random, the direction of change is unpredictable.

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#Section 3: Genetics, Cellular and Molecular Biology

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase

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#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8343

#Section 3: Genetics, Cellular and Molecular Biology

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8342

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8341

#Section 3: Genetics, Cellular and Molecular Biology

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

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#Section 3: Genetics, Cellular and Molecular Biology

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.