Smo has seven TM α helices, is a member of the GPCR superfamily, and is related in sequence to the Fz.

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Kinesin-1 

is regulated by a 

head-to-tail interaction

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#XL - Q Biochemistry

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Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene

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Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin. 

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Troponin C is closely related to the ubiquitous 

Ca2+-binding protein calmodulin

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Binding of Ca2+ ions to TN-C

triggers movement of TM to a new position on the filament, thereby exposing the myosin-binding sites on actin.