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Acetyl-CoA inhibits the transacetylase component whereas NADH inhibits the dihydrolipoyl dehydrogenase component. 

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The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)

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Eukaryotic cells have two isozymes of aconitase

• The mitochondrial isozyme (convert citrate to isocitrate in the citric acid cycle)

• The cytosolic isozyme 

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#Id: 364

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Pyruvate kinase acts in the nucleus to regulate the transcription of genes that respond to thyroid hormone. Glyceraldehyde 3-phosphate dehydrogenase moonlights both as uracil DNA glycosylase, effecting the repair of damaged DNA, and as a regulator of histone H2B transcription. 

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The enzyme that catalyzes this reversible reaction is called succinyl-CoA synthetase or succinic thiokinase

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#Id: 8674

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