TLS Online TPP Program

#Id: 9447

#XL - T Zoology

Large family of cytokines:

Interleukins

Interferons

Growth hormone

Prolactin

G-CSF

Thrombopoietin

Erythropoietin

TLS Online TPP Program

#Id: 9448

#XL - T Zoology

Receptor Homodimerization 

Cytokines (erythropoietin) activate receptors by forming dimers of two identical cytokine receptor proteins

TLS Online TPP Program

#Id: 9450

#XL - T Zoology

Receptor hetero-dimerization or hetero-oligomerization 

Other cytokines (interleukins and interferons) bind simultaneously to two or more different cytokine receptors

TLS Online TPP Program

#Id: 9451

#XL - T Zoology

The extracellular domain of cytokine receptors are constructed of two subdomains, each contains seven conserved β strands folded together

TLS Online TPP Program

#Id: 9452

#XL - T Zoology

In cytokine receptors, 

the receptor and kinase are separate polypeptides, encoded by different genes, yet are bound tightly together.

TLS Online TPP Program

#Id: 9454

#XL - T Zoology

In cytokine receptors, the tightly bound kinase is known as a JAK kinase.