Positive Costimulatory Receptors: ICOS

ICOS binds to another member of the growing B7 family, ICOS-ligand (ICOS-L), which is also expressed on a subset of activated APCs.

ICOS plays a key role in maintaining the activity of already differentiated effector and memory T cells.

TLS Online TPP Program

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#XL - R Botany

III. Underground Stem modification

TLS Online TPP Program

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#XL - Q Biochemistry

Lineweaver-Burk plot showing the effect of uncompetitive inhibition; (b) the same, showing plots for several inhibitor concentrations at fixed enzyme concentration.

TLS Online TPP Program

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#XL - Q Biochemistry

The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

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#XL - T Zoology

Following securin degradation and a decrease in mitotic CDK activity, separase cleaves the Scc1 subunit, breaking the cohesin circles.

TLS Online TPP Program

#Id: 10060

#XL - T Zoology

The formation of many cell-cell adhesions entails two types of molecular interactions:

1.Trans binding interactions 

2. Cis binding interactions