Engineering T cells contain specially engineered T cell receptors, called chimeric antigen receptors, and the modified cells are called CAR T cells

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An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β.

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TLS Online TPP Program

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Integrins function as transmembrane linkers (integrators) between the extracellular matrix and the actin cytoskeleton.

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Integrins bind extracellular matrix (ECM) glycoproteins, 

1. Laminins  

2. Collagens 

3. Fibronectin

4. Vitronectin

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Fibronectin binds to integrin through an RGD motif.

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The binding of integrins to their ligands depends on extracellular divalent cations(Ca+2 & Mg+2)