The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 9805

#XL - R Botany

In higher plants the phytochrome chromophore is a linear tetrapyrrole called phytochromobilin

TLS Online TPP Program

#Id: 9806

#XL - R Botany

Pr chromophore undergoes a cis–trans isomerization between carbons 15 and 16 and rotation of the C14-C15 single bond on red light exposure.

TLS Online TPP Program

#Id: 9807

#XL - R Botany

Phytochromobilin is synthesized in plastids from chlorophyll biosynthetic pathway and transported into cytosol by a passive process.

TLS Online TPP Program

#Id: 9808

#XL - R Botany

Phytochromobilin is exported from the plastid to the cytosol where it autocatalytically attaches to the PHY apoprotein through a thioether linkage to a cysteine residue.

TLS Online TPP Program

#Id: 9809

#XL - R Botany

hy1 and hy2 mutant are chromophore biosynthesis mutant: which fail to supress hypocotyl elongation

TLS Online TPP Program

#Id: 9810

#XL - R Botany

Pfr is the physiologically active forms of Phytochrome

Wild type: short hypocotyl by white light

hy mutant (phytochrome mutant): long hypocotyl by white light