The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 8892

#XL - R Botany

Amphitelic attachment, 

sister kinetochores attach to microtubules emanating from opposite spindle poles, they are stably attached

TLS Online TPP Program

#Id: 5504

#XL - T Zoology

Intermediate - Many perennial herbs adopt a mixture of these strategies and tend to lie in the center of Grime’s triangle.One cannot be a good stress tolerator and a good competitor at the same time

TLS Online TPP Program

#Id: 356

#XL - R Botany

The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)

TLS Online TPP Program

#Id: 9535

#XL - T Zoology

TLS Online TPP Program

#Id: 8394

#XL - Q Biochemistry

When the Ca2+ levels drop:

Myosin LC is dephosphorylated by MLC phosphatase, causing muscle relaxation.