Quadrate method

TLS Online TPP Program

#Id: 9645

#XL - T Zoology

Active Ras⋅GTP binds to the N-terminal autoinhibitory domain of Raf, altering its conformation and allowing the phosphate attached to this domain to be removed by cytosolic phosphatases, causing loss of 14-3-3 binding.

TLS Online TPP Program

#Id: 9646

#XL - T Zoology

Active Raf phosphorylates MEK on one or two serine residues in its activation loop, activating MEK kinase activity

TLS Online TPP Program

#Id: 9647

#XL - T Zoology

Constitutively active Raf kinase

a glutamic acid substitution for the valine at position 600

TLS Online TPP Program

#Id: 9648

#XL - T Zoology

MEK is a dual-specificity protein kinase

phosphorylates its target proteins on both tyrosine and serine/threonine

TLS Online TPP Program

#Id: 9649

#XL - T Zoology

In humans, there are three RAS, three Raf, two MEK, and two MAP proteins.

TLS Online TPP Program

#Id: 9650

#XL - T Zoology

Mammalian MAP kinases include  Jun N-terminal kinases and p38 kinases, which are activated by signaling pathways in response to various types of stresses