There are four known forces that are involved in evolution:

1)mutation,

2) genetic drift

3) gene flow or migration

4) selection.

TLS Online TPP Program

#Id: 10047

#XL - T Zoology

Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

TLS Online TPP Program

#Id: 10048

#XL - T Zoology

ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.

TLS Online TPP Program

#Id: 10049

#XL - T Zoology

ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)

TLS Online TPP Program

#Id: 10050

#XL - T Zoology

Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell

TLS Online TPP Program

#Id: 10051

#XL - T Zoology

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

TLS Online TPP Program

#Id: 10052

#XL - T Zoology

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase