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TLS Online TPP Program

#Id: 7839



#XL - T Zoology #Carbohydrate #Part B Pointers
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TLS Online TPP Program

#Id: 9642

#XL - T Zoology

In unstimulated cells, 
Raf is phosphorylated by several cytosolic kinases on two sites:
1. Serine/threonine kinase domain 
2. N-terminal autoinhibitory domain

TLS Online TPP Program

#Id: 9643

#XL - T Zoology

Molecular Handcuff 
Phosphorylation of Raf is recognize by protein 14-3-3 dimer, which locks the autoinhibitory domain in a position where it blocks and inhibits the kinase active site

TLS Online TPP Program

#Id: 9644

#XL - T Zoology

TLS Online TPP Program

#Id: 9645

#XL - T Zoology

Active Rasâ‹…GTP binds to the N-terminal autoinhibitory domain of Raf, altering its conformation and allowing the phosphate attached to this domain to be removed by cytosolic phosphatases, causing loss of 14-3-3 binding.

TLS Online TPP Program

#Id: 9646

#XL - T Zoology

Active Raf phosphorylates MEK on one or two serine residues in its activation loop, activating MEK kinase activity


TLS Online TPP Program

#Id: 9647

#XL - T Zoology

Constitutively active Raf kinase
a glutamic acid substitution for the valine at position 600

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