The binding partners for MICOS in the outer membrane are Tom and SAM protein complexes, (involved in import of proteins into the mitochondria). 

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#XL - Q Biochemistry

The binding partners for MICOS in the outer membrane are Tom and SAM protein complexes, (involved in import of proteins into the mitochondria). 

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#Id: 8547

#XL - Q Biochemistry

The irreversible inhibitors cannot be removed by simple physical techniques such as dialysis, is to reduce the amount of enzyme available for reaction.

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#Id: 8548

#XL - Q Biochemistry

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#Id: 8549

#XL - Q Biochemistry

The irreversible inhibition involves reactions with a functional group, such as hydroxyl or sulphydryl, or with a metal atom in the active site or a distinct allosteric site.

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#Id: 8550

#XL - Q Biochemistry

diisopropylphosphofluoridate, reacts with a serine OH group in the active site of esterases such as acetylcholinesterase/chymotrypsin, whilst the organomercury compound p-hydroxymercuribenzoate reacts with a cysteine group, in both cases resulting in covalent bond formation and enzyme inhibition.

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di-isopropylphosphofluoridate (DFP), phenylmethyl sulphonylfluoride

(PMSF) and tosylphenylalanyl-chloromethylketone (TPCK) (all serine protease inhibitors); 

iodoacetate and cystatin (thiol protease inhibitors); 

pepstatin (aspartic protease inhibitor); 

EDTA and 1,10-phenanthroline (metalloprotease inhibitors); and amastatin and bestatin (exopeptidase inhibitors).

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#Id: 8552

#XL - Q Biochemistry