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mtDNA is located in the mitochondrial matrix, and in the rapidly growing cells, mtDNA is often seen in regions devoid of densely stacked cristae.

#XL - Q Biochemistry #Mitochondria #Part B Pointers
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They supposed that such mutant forms constituted new species and thus believed that natural selection was not necessary to account for the origin of species. The last influential mutationist was Richard Goldschmidt

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#XL - Q Biochemistry

Unassembled or misfolded proteins in the ER are often transported back to the cytosol, where they are degraded in the ubiquitin-proteasome pathway


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#XL - Q Biochemistry

Deletions in mtDNA cause another set of diseases:
Chronic progressive external ophthalmoplegia
Kearns–Sayre syndrome

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HER2 can signal only by forming heterodimers with ligand-bound HER1, HER3, or HER4

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