In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

TLS Online TPP Program

#Id: 7908

#XL - Q Biochemistry

In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

TLS Online TPP Program

#Id: 8651

#XL - T Zoology

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

TLS Online TPP Program

#Id: 8652

#XL - T Zoology

TLS Online TPP Program

#Id: 8653

#XL - T Zoology

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

TLS Online TPP Program

#Id: 8654

#XL - T Zoology

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

TLS Online TPP Program

#Id: 8655

#XL - T Zoology

TLS Online TPP Program

#Id: 8656

#XL - T Zoology