Membrane and soluble secretory proteins synthesized on the rough ER undergo four principal modifications before they reach their final destinations: 

(1) Glycosylation in the ER and Golgi complex

(2) Formation of disulfide bonds in the ER

(3) Proper folding of polypeptide chains and assembly of multisubunit proteins in the ER

(4) Specific proteolytic cleavages in the ER, Golgi complex, and secretory vesicles

TLS Online TPP Program

#Id: 1318

#XL - T Zoology

Rod cells sense light via light-sensitive GPCR known as Rhodopsin.

TLS Online TPP Program

#Id: 1319

#XL - T Zoology

The heterotrimeric G protein coupled to rhodopsin, called Transducin.

TLS Online TPP Program

#Id: 1320

#XL - T Zoology

On absorption of a photon, the retinal moiety of rhodopsin is immediately converted into 11-cis-retinal to the all-trans retinal.

TLS Online TPP Program

#Id: 1321

#XL - T Zoology

Rapid Termination of the Rhodopsin Signal Transduction Pathway Rhodopsin kinase & Arrestin.

TLS Online TPP Program

#Id: 1322

#XL - T Zoology

Gαi activate α2-Adrenergic receptor

TLS Online TPP Program

#Id: 1323

#XL - T Zoology

Positive and negative regulation of adenylyl cyclase activity-

Gαs-coupled receptors

Gαi-coupled receptors