Defects in LIS1 

Miller-Dieker lissencephaly

means “smooth brain”

TLS Online TPP Program

#Id: 324

#XL - R Botany

TLS Online TPP Program

#Id: 326

#XL - R Botany

When blood glucose rises above 5 mM, hexokinase IV activity increases, but hexokinase I is already operating near Vmax and cannot respond to an increase in glucose concentration. 

TLS Online TPP Program

#Id: 327

#XL - R Botany

Hexokinase IV is subject to inhibition by the reversible binding of a regulatory protein specific to liver

TLS Online TPP Program

#Id: 333

#XL - R Botany

Fructose 2,6-bisphosphate binds to its allosteric site on PFK-1, it increases the enzyme’s affinity for its substrate fructose 6-phosphate and reduces its affinity for the allosteric inhibitors ATP and citrate

TLS Online TPP Program

#Id: 335

#XL - R Botany

Glucagon lowers the cellular level of fructose 2,6 bisphosphate, inhibiting glycolysis and stimulating gluconeogenesis.

TLS Online TPP Program

#Id: 342

#XL - R Botany

Accumulation of alanine, which can be synthesized from pyruvate in one step, allosterically inhibits pyruvate kinase, slowing the production of pyruvate by glycolysis