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1. Alanine is can be mutated to

#XL - Q Biochemistry #Amino Acids #Part B Pointers
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TLS Online TPP Program

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Hexokinase IV is subject to inhibition by the reversible binding of a regulatory protein specific to liver

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Fructose 2,6-bisphosphate binds to its allosteric site on PFK-1, it increases the enzyme’s affinity for its substrate fructose 6-phosphate and reduces its affinity for the allosteric inhibitors ATP and citrate


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Glucagon lowers the cellular level of fructose 2,6 bisphosphate, inhibiting glycolysis and stimulating gluconeogenesis.

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Accumulation of alanine, which can be synthesized from pyruvate in one step, allosterically inhibits pyruvate kinase, slowing the production of pyruvate by glycolysis

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The liver PK isozyme (L form) is regulated by glucagon

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Pyruvate Carboxylase
a mitochondrial enzyme that requires the coenzyme biotin, converts the pyruvate to oxaloacetate

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