In most mammalian tissues, ubiquinone (also called coenzyme Q) has 10 isoprene units.

Dolichols of animals have 17 to 21 isoprene units (85 to 105 carbon atoms), bacterial dolichols have 11, and those of plants and fungi have 14 to 24.

TLS Online TPP Program

#Id: 8131

#XL - Q Biochemistry

In most mammalian tissues, ubiquinone (also called coenzyme Q) has 10 isoprene units.

Dolichols of animals have 17 to 21 isoprene units (85 to 105 carbon atoms), bacterial dolichols have 11, and those of plants and fungi have 14 to 24.

TLS Online TPP Program

#Id: 8131

#XL - T Zoology

In most mammalian tissues, ubiquinone (also called coenzyme Q) has 10 isoprene units.

Dolichols of animals have 17 to 21 isoprene units (85 to 105 carbon atoms), bacterial dolichols have 11, and those of plants and fungi have 14 to 24.

TLS Online TPP Program

#Id: 9458

#XL - T Zoology

JAK kinases become activated after ligand binding and

receptor dimerization

TLS Online TPP Program

#Id: 9459

#XL - T Zoology

Ligand binding triggers a conformational change in the JAKs & they phosphorylate each other on a critical tyrosine in the activation loop which greatly enhances kinase activity

TLS Online TPP Program

#Id: 9461

#XL - T Zoology

Active JAK kinase phosphorylates several tyrosine residues in the receptor’s cytosolic domain and activates a STAT transcription factor that moves directly to the nucleus

TLS Online TPP Program

#Id: 9462

#XL - T Zoology

All STAT proteins contain: 

an N-terminal DNA-binding domain

an SH2 domain

a C-terminal domain with a critical tyrosine residue

TLS Online TPP Program

#Id: 9463

#XL - T Zoology

SH2 domain (Src homology 2 domain) 

homology with a region in the Src cytosolic tyrosine kinase encoded by the src gene.

TLS Online TPP Program

#Id: 9464

#XL - T Zoology

The SH2 domain binds strongly to short target peptides containing a critical four-residue core sequence:: 

phosphotyrosine–glutamic acid–glutamic acid–isoleucine