Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 8167

#XL - Q Biochemistry

Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 9279

#XL - R Botany

The binding of Nod factors to the Nod factor receptors (NFRs), which contain extracellular LysM motifs, initiates an interaction with the conserved SYMRK receptor-like kinases containing a leucine-rich repeat (LRR) domain.

TLS Online TPP Program

#Id: 9280

#XL - R Botany

The interaction between NFR and SYMRK initiates calcium spiking in the nucleus, presumably via a second messenger molecule.

Core symbiotic genes are activated.

Cytokinin signaling is initiated.

TLS Online TPP Program

#Id: 9281

#XL - R Botany

Root hair cellular responses to bacterial Nod factor

TLS Online TPP Program

#Id: 9282

#XL - R Botany

Plant genes expressed early, or in the absence of bacterial infection, are termed “early nodulins” or ENOD

TLS Online TPP Program

#Id: 9283

#XL - R Botany

Three factors are important in maintaining low O2 concentrations in nodules. 

First, entry of O2 into the nodule is controlled by a variable‐permeability barrier in the nodule parenchyma

TLS Online TPP Program

#Id: 9284

#XL - R Botany

O2‐binding plant protein Lb plays an active role in regulating and delivering O2 in the infected cells

Bacterial respiration is the major O2 sink