TLS Online TPP Program

#Id: 9452

#XL - T Zoology

In cytokine receptors, 

the receptor and kinase are separate polypeptides, encoded by different genes, yet are bound tightly together.

TLS Online TPP Program

#Id: 9454

#XL - T Zoology

In cytokine receptors, the tightly bound kinase is known as a JAK kinase.

TLS Online TPP Program

#Id: 9455

#XL - T Zoology

Cytokine receptors are stably associated with one or two of the four known JAKs:

JAK1, JAK2, JAK3, and Tyk2

TLS Online TPP Program

#Id: 9457

#XL - T Zoology

Each members of JAK family of kinases contains:

An N-terminal domain that binds to the receptor

A C-terminal kinase domain 

A middle pseudokinase domain

TLS Online TPP Program

#Id: 9458

#XL - T Zoology

JAK kinases become activated after ligand binding and

receptor dimerization

TLS Online TPP Program

#Id: 9459

#XL - T Zoology

Ligand binding triggers a conformational change in the JAKs & they phosphorylate each other on a critical tyrosine in the activation loop which greatly enhances kinase activity