Nonphosphorylated CDK bound to one of its cyclin partners has minimal but detectable protein kinase activity in vitro, although it may be essentially inactive in vivo.

TLS Online TPP Program

#Id: 8611

#XL - T Zoology

Nonphosphorylated CDK bound to one of its cyclin partners has minimal but detectable protein kinase activity in vitro, although it may be essentially inactive in vivo.

TLS Online TPP Program

#Id: 9977

#XL - T Zoology

Unphosphorylated β-catenin translocates to the nucleus.

TLS Online TPP Program

#Id: 9978

#XL - T Zoology

β-catenin binds to TCF to displace the Gro repressor and recruits co-activator proteins Pygo, LGS, to activate target gene expression.

TLS Online TPP Program

#Id: 9979

#XL - T Zoology

Active Wnt signaling leads to the secretion of Notum.

TLS Online TPP Program

#Id: 9980

#XL - T Zoology

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.

TLS Online TPP Program

#Id: 9981

#XL - T Zoology

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.

TLS Online TPP Program

#Id: 9982

#XL - T Zoology

Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.