Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

TLS Online TPP Program

#Id: 8644

#XL - T Zoology

Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

TLS Online TPP Program

#Id: 10003

#XL - T Zoology

Mice homozygous for a null allele of dhh exhibit defective spermatogenesis

TLS Online TPP Program

#Id: 10004

#XL - T Zoology

Indian hedgehog is expressed in the gut and cartilage and is important in postnatal bone growth

TLS Online TPP Program

#Id: 10005

#XL - T Zoology

Sonic hedgehog is responsible for assuring that motor neurons come only from the ventral portion of the neural tube & essential for normal patterning of the limbs

TLS Online TPP Program

#Id: 10006

#XL - T Zoology

Hedgehog protein with autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion.

TLS Online TPP Program

#Id: 10007

#XL - T Zoology

TLS Online TPP Program

#Id: 10008

#XL - T Zoology

The freed C-terminal is not involved in signaling and is often degraded, whereas the N-terminal becomes the active Hedgehog protein intended for secretion