Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

TLS Online TPP Program

#Id: 8645

#XL - T Zoology

Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

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#Id: 8644

#XL - T Zoology

Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

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#XL - T Zoology

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

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TLS Online TPP Program

#Id: 8648

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During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

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During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

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#Id: 8650

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G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition