Smc1 and Smc3 are members of the structural

maintenance of chromosomes (SMC) protein family, characterized by globular domains at the N- & C-termini connected by a long α helix, bind and hydrolyze ATP.

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#Id: 8856

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Smc1 and Smc3 are members of the structural

maintenance of chromosomes (SMC) protein family, characterized by globular domains at the N- & C-termini connected by a long α helix, bind and hydrolyze ATP.

TLS Online TPP Program

#Id: 8894

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Syntelic attachment 

Both kinetochores of a sister chromatid pair can attach to microtubules from the same pole

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#Id: 8895

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Monotelic attachment 

only one kinetochore can attach to microtubules

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#Id: 8897

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Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

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#Id: 8898

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If Amphitelic attachment occur  Microtubules pull kinetochores; cohesins resist this pulling force. The resulting tension leads to the outer kinetochore component Ndc80 being pulled away from the protein kinase Aurora B

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#Id: 8900

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The Aurora protein kinase family members Aurora A and Aurora B and their associated regulatory factors sense kinetochores that are not under tension and sever these microtubule attachments

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#Id: 8598

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Labile factors called cyclins drive the progression of cells through different stages of the cell cycle by binding to CDKs.