The levels of insulin present in the body and the Kd for binding of insulin to its receptor on liver cells,

1.4 × 10−10 M (0.14 nM). The normal concentration of insulin in the blood is  5 × 10−12 M. 

The fraction of insulin receptors with bound insulin, [RL]/[RT], at equilibrium as 0.0344

TLS Online TPP Program

#Id: 10044

#XL - T Zoology

In Notch/Delta pathway, 

signaling molecule is Delta, an integral membrane protein bound to the surface of the signaling cell.

TLS Online TPP Program

#Id: 10045

#XL - T Zoology

In Notch/Delta pathway, 

Notch is receptor protein, on a neighboring responding cell

TLS Online TPP Program

#Id: 10046

#XL - T Zoology

In the absence of Delta, 

TM subunit of Notch on the surface of a responding cell is non-covalently associated with its extracellular subunit; extracellular domain is folded

TLS Online TPP Program

#Id: 10047

#XL - T Zoology

Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

TLS Online TPP Program

#Id: 10048

#XL - T Zoology

ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.

TLS Online TPP Program

#Id: 10049

#XL - T Zoology

ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)