RIII, also called β-glycan, is a cell-surface proteoglycan.

TLS Online TPP Program

#Id: 8218

#XL - Q Biochemistry

Sorting signal that directs lysosomal hydrolases from the TGN to the late endosome is- Mannose 6-phosphate (M6P).

TLS Online TPP Program

#Id: 8217

#XL - Q Biochemistry

In selective autophagy

specific cargo is packaged into autophagosomes that tend to contain little cytosol, mediates the degradation of worn out, or unwanted, mitochondria, peroxisomes, ribosomes, and ER; used to destroy invading microbes.

TLS Online TPP Program

#Id: 8216

#XL - Q Biochemistry

In nonselective autophagy, a bulk portion of cytoplasm is sequestered in autophagosomes

TLS Online TPP Program

#Id: 8215

#XL - Q Biochemistry

Autophagy can be either

• Nonselective autophagy

• Selective autophagy

TLS Online TPP Program

#Id: 8213

#XL - Q Biochemistry

Autophagy occurs in the following sequence of steps:

Induction by activation of mTOR complex 1

• Nucleation of autophagosome formation by ATG9

• Closure of the membrane cup to form autophagosome

• Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

• Digestion of the inner membrane and the lumenal contents of the autophagosome

TLS Online TPP Program

#Id: 8212

#XL - Q Biochemistry