R-Smads comprising: 

An N-terminal MH1 domain

A central proline-rich linker 

A C-terminal MH2 domain

TLS Online TPP Program

#Id: 8337

#XL - Q Biochemistry

Profilin – G-actin nucleotide exchange (ADP to ATP) 

Cofilin – F-actin disassembly

Thymosin B-4 – G-actin monomer sequestering

TLS Online TPP Program

#Id: 8336

#XL - Q Biochemistry

Actin filament treadmilling is accelerated by:

Profilin and Cofilin

TLS Online TPP Program

#Id: 8335

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8334

#XL - Q Biochemistry

Phalloidin 

isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.

TLS Online TPP Program

#Id: 8333

#XL - Q Biochemistry

Jasplakinolide,

a sponge toxin, enhances nucleation by binding and stabilizing actin dimers and lowering the Cc.

TLS Online TPP Program

#Id: 8332

#XL - Q Biochemistry

Latrunculin, 

a toxin secreted by sponges, binds and sequesters G-actin