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TLS Online TPP Program

#Id: 9363

Phosphorylation of two serines in Ser-X-Ser motif at the extreme C-terminus of the MH2 domain by the activated RI separates the two domains, exposing the NLS for binding to importins

#XL - T Zoology #TGF-β Signaling #Part B Pointers
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TLS Online TPP Program

#Id: 8884

#XL - T Zoology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.
TLS Online TPP Program

#Id: 8885

#XL - T Zoology
TLS Online TPP Program

#Id: 8886

#XL - T Zoology
TLS Online TPP Program

#Id: 8887

#XL - T Zoology

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 
TLS Online TPP Program

#Id: 8888

#XL - T Zoology

A key function of mitotic CDKs, together with other protein kinases and ubiquitin-protein ligases, is to induce the formation of the mitotic spindle, also known as the mitotic apparatus.
TLS Online TPP Program

#Id: 8889

#XL - T Zoology

Centrosomes contain γ tubulin, which forms specific ringlike complexes (γ TuRCs) that, have the ability to nucleate microtubules and form a bipolar spindle